Premarin vaginal cream 0.625 mg (14 gm) is a prescription medicine for women with moderate to severe painful intercourse due to menopause. Unlike over the counter lubricants, this vaginal formulation delivers estrogens and acts to relieve pain and other symptoms associated with menopause. Premarin is a conjugated estrogen cream. Estrogen is a female hormone. Conjugated estrogens vaginal cream belongs to the class of medications known as estrogen replacement therapy. This drug is used by the women who suffer from vaginal and urinary menopausal symptoms such as itching, burning, dryness around the vaginal area, difficulty in urination, and excruciating and pain during sexual intercourse.

In women, menopause generally occurs somewhere between 45-55 years of age. After menopause, the body produces less amount of estrogen. Menopause is hence marked by symptoms such as "hot flushes", night sweats, vaginal dryness, itching and painful sexual intercourse.

Conjugated estrogens are like the hormones produced by the ovaries before menopause; they can help to control the symptoms. Along with progesterone, the estrogen is used to treat women who have had their uterus or "womb” removed.